N-Chlorotaurine (NCT) is a natural anti-infective/anti-inflammatory biochemical, which possesses several therapeutic benefits. Most importantly, it helps the human immune system maintain the delicate balance between rapidly killing pathogens on the one hand, while simultaneously protecting human cells and tissue on the other hand.
A therapeutic concentration of 1% NCT aqueous solution in the presence of human body fluids at normal body temperature (37°C) has demonstrated rapid in vitro killing activity against viruses (enveloped, e.g. SARS-CoV-2, and non-enveloped), including:
- Influenza virus A
- Influenza virus (H1N1): NCT completely inactivated the virus within 1 minute
- Respiratory Syncytial Virus (RSV): After a rapid drop within the first 5 minutes, NCT completely inactivated the virus within 15 minutes
- Herpes simplex virus type 1
- Herpes simplex virus type 2
N-Chlorotaurine (NCT) is involved in the termination of acute inflammation (which is believed to be its main function in the human innate immune defense system) by directly decreasing the production of tissue-damaging mediators created by white blood cells when they encounter a pathogen and initiate inflammation (during the innate immune response).
NCT appears to inhibit the production by stimulated white blood cells of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) during acute inflammation.
NCT also reduces the production of nitrous oxide (NO) and prostaglandin E2 (PGE2) and decreases the activity of matrix metalloproteinases.
N-Chlorotaurine (NCT) can be pharmaceutically formulated as a topical antiseptic medication (comprised of the pure sodium salt dissolved in water). A therapeutic concentration of 1% NCT in aqueous solution (medicinal NCT) delivers approximately 1000x the physiological concentration of NCT which is produced by white blood cells activated during the innate immune response in the human body.
NCT inactivates a broad spectrum of virtually all infectious pathogens, i.e., bacteria (Gram-positive and Gram-negative), viruses (enveloped, e.g. SARS-CoV-2, and non-enveloped), yeasts, molds, fungi and protozoa.
N-Chlorotaurine (NCT) has demonstrated dose-dependent anticoagulant activity in all the main coagulation tests in human blood, including prolonging prothrombin time, activated partial thromboplastin time, thrombin time, decreasing fibrinogen, and direct thrombin inhibition.
After N-Chlorotaurine (NCT) oxidizes inside the body, it immediately breaks down into taurine and chloride, which are already present in the human body (the human body is made up of 0.1% taurine and 0.15% chloride by weight). Taurine is the most abundant free amino acid in humans. It is an essential antioxidant that provides crucial chemical protection to cells (cytoprotection) and it helps attenuate cell death (apoptosis).
N-Chlorotaurine’s (NCT’s) ‘chlorine covers’ on a pathogen’s surface may signal that the pathogen is dead. This signal prompts the formation of antibodies, by switching from the innate immune response nonspecific killing mode (i.e. protective in the short term) to the acquired immune response antigen specific mode (i.e. providing long-term protection against future challenge).