N-Chlorotaurine’s (NCT’s) helps fight COVID-19 by directly killing the SARS-CoV-2 virus, controlling inflammation, preventing secondary infections/thrombosis, and protecting living cells by supplying an essential antioxidant through its primary byproduct, the amino acid taurine. NCT’s therapeutic benefits against COVID-19 include the following:
Antiviral
N-Chlorotaurine (NCT) supports the body’s anti-pathogen innate immune response to COVID-19. It has recently demonstrated rapid in vitro antiviral/virucidal activity against the SARS-CoV-2 virus in the presence of human body fluids at normal body temperature (37°C), where a therapeutic concentration of 1% NCT aqueous solution significantly inactivated the virus by 50% within 1 minute and by 97% after 10 minutes (>99% after 30minutes).
Anti-inflammatory
N-Chlorotaurine (NCT) supports the body’s anti-inflammatory innate immune response to COVID-19. NCT is involved in the termination of acute inflammation (which is believed to be its main function in the human innate immune defense system) by directly decreasing the production of tissue-damaging mediators created by white blood cells when they encounter a pathogen and initiate inflammation (during the innate immune response). NCT helps influence the aggressive inflammatory response by downregulating the ‘cytokine storm’ and prevent airway damage in severe ill patients with SARS-CoV-2 infection.
Antiseptic
N-Chlorotaurine (NCT) is an antiseptic that helps prevent secondary infections. NCT is active against bacteria and fungi, including multi-resistant ones, and may prevent super- and secondary infections, which frequently are a life-threatening problem in COVID-19 patients.
Anticoagulant
N-Chlorotaurine (NCT) has demonstrated dose-dependent anticoagulant activity in all the main coagulation tests in human blood, including prolonging prothrombin time, activated partial thromboplastin time, thrombin time, decreasing fibrinogen, and direct thrombin inhibition. Since most COVID-19 thrombotic events (87%) develop inside the lungs as a pulmonary embolism (in situ pulmonary thrombosis), the direct delivery of an inhaled anticoagulant like NCT should help prevent developing a dangerous thrombosis in the lung.
Antioxidant (byproduct)
After N-Chlorotaurine (NCT) oxidizes inside the body, it immediately breaks down into taurine and chloride, which are already present in the human body (the human body is made up of 0.1% taurine and 0.15% chloride by weight). Taurine is the most abundant free amino acid in humans. It is an essential antioxidant that provides crucial chemical protection to cells (cytoprotection) and it helps attenuate cell death (apoptosis).
Antibody (signal)
N-Chlorotaurine’s (NCT’s) ‘chlorine covers’ on the surface of a SARS-CoV-2 virus may signal that the pathogen is dead. This signal prompts the formation of antibodies, by switching from the innate immune response nonspecific killing mode (i.e. protective in the short term) to the acquired immune response antigen specific mode (i.e. providing long-term protection against future challenge).