Safety and Tolerabilty

  1. Arnitz R et al. Tolerability of inhaled N-chlorotaurine in humans: a double-blind randomized phase I clinical study. Ther Adv Respir Dis. 2018; 12: 1-14.
  2. Nagl M et al. Tolerability of inhaled N-chlorotaurine versus sodium chloride in the mouse. J Med Res Prac. 2013; 2(6): 163-170.
  3. Schwienbacher M et al. Tolerability of inhaled N-chlorotaurine in an acute pig streptococcal lower airway inflammation model. BMC Infectious Diseases. 2011; 11:231.
  4. Geiger R et al. Tolerability of inhaled N-chlorotaurine in the pig model. BMC Pulm Med. 2009; 9:33.
  5. Teuchner B et al. Tolerability of N-chlorotaurine plus ammonium chloride in the rabbit and human eye – a phase 1 clinical study. Graefes Arch Clin Exp Ophthalmol. 2008; 246(12):1723-30.
  6. Huber J et al. Tolerability of N-chlorotaurine in the bovine mammary gland. Journal of Dairy Research. 2008; 75: 248-256.
  7. Arnitz R et al. A novel N-chlorotaurine-corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro. Acta Oto-Laryngologica. 2006; 126: 291-294.
  8. Neher A et al. Tolerability of N-chlorotaurine in chronic rhinosinusitis applied via yamik catheter. Auris Nasus Larynx. 2005; 32: 359-364.
  9. Teuchner B et al. Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis – a double-blind randomized phase 2 clinical trial. J Ocular Pharmacol Ther. 2005; 21: 157–165.
  10. Neher A et al. Tolerability of N-chlorotaurine in the guinea pig middle ear – a pilot study using an improved application system. Ann Otol Rhino Larygol. 2004; 113: 76-81.
  11. Neher A et al. Acute Otitus Externa: Efficacy and Tolerability of N-Chlorotaurine, a Novel Endogenous Antiseptic Agent. Laryngoscope. 2004; 114: 850-854.
  12. Hofer E et al. In vitro study on the influence of N-chlorotaurine on the ciliary beat frequency of nasal mucosa. Am J Rhinol. 2003; 17: 149-152.
  13. Nagl M et al. Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for treatment of chronic leg ulcers with a purulent coating: a randomized phase II study. British Journal of Dermatology. 2003; 149: 590-597.
  14. Neher A et al. N-chlorotaurine, a novel endogenous antimicrobial agent: tolerability tested in a mouse model. Arch Otolaryng Head Neck Surg. 2001; 127(5): 530-533.
  15. Nagl M et al. Tolerance of N-chlorotaurine, a new antimicrobial agent, in infectious conjunctivitis – a phase II pilot study. Ophthalmologica. 2000; 214(2): 111-114.
  16. Nagl M et al. Tolerance and bactericidal action of N-chlorotaurine in a urinary tract infection by an omniresistant Pseudomonas aeruginosa. Zent bl Bakteriol 1998; 288(2): 217-223.
  17. Nagl M et al. Tolerance of N-chlorotaurine, an endogenous antimicrobial agent, in the rabbit and human eye – a phase I clinical study. J Ocular Pharmacol Ther. 1998; 14(3): 285-292.
  18. Cantin A, Taurine modulation of hypochlorous acid-induced lung epithelial cell injury in vitro. Role of anion transport. J Clin Invest. 1994; 93(2): 606-14.
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